Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4835505 | 0.91 | LMNA (0.40) | LMNAALDH3A1MAPTNPC1RAB9A | |
| SCHEMBL11533565 | 0.86 | MAPK1 (0.50) | LMNAMAPTNPC1RAB9AKMT2A | |
| SCHEMBL11528799 | 0.86 | AKR1C3 (0.47) | LMNAMAPTNPC1RAB9AKMT2A | |
| SCHEMBL25101501 | 0.85 | LMNA (0.47) | LMNAMAPTNPC1RAB9AHTT | |
| SCHEMBL11531797 | 0.85 | LMNA (0.39) | LMNAMAPTNPC1RAB9AHTT | |
| SCHEMBL11528849 | 0.80 | KMT2A (0.45) | LMNAMAPTNPC1RAB9AHTT | |
| SCHEMBL11530416 | 0.77 | ALDH1A1 (0.50) | LMNAMAPTNPC1RAB9AKMT2A | |
| SCHEMBL4837038 | 0.76 | ATM (0.39) | LMNAALDH3A1MAPTRAB9AHTT | |
| SCHEMBL11529600 | 0.76 | ALDH3A1 (0.38) | LMNAALDH3A1MAPTRAB9AHTT | |
| SCHEMBL11532019 | 0.75 | KMT2A (0.44) | LMNAMAPTNPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4172831-A | CENTRAL NERVOUS SYSTEM | LILLY INDUSTRIES LIMITED (GB) | 1979-10-30 | — | — | US | disclosed |
| US-4115574-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |
| US-4115568-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |