Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28980204 | 0.76 | PIK3CA (0.36) | PIK3CAPIK3CG | |
| SCHEMBL21899214 | 0.74 | PIK3CA (0.35) | PIK3CAPIK3CG | |
| SCHEMBL27892601 | 0.72 | NOTUM (0.37) | PIK3CAPIK3CG | |
| SCHEMBL11528398 | 0.72 | PIK3CA (0.35) | PIK3CAPIK3CG | |
| SCHEMBL9700791 | 0.71 | LOXL2 (0.34) | PIK3CAPIK3CG | |
| SCHEMBL3464438 | 0.67 | PIK3CA (0.37) | PIK3CAPIK3CG | |
| SCHEMBL31304016 | 0.66 | NOTUM (0.49) | PIK3CAPIK3CGCA12CA1CA2 | |
| SCHEMBL30580704 | 0.66 | PTGS2 (0.43) | PIK3CAPIK3CGCA12CA1CA2 | |
| SCHEMBL17796279 | 0.65 | — | — | |
| SCHEMBL27876055 | 0.65 | KLKB1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198710-A1 | PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS COMPRISING INHIBITORS OF THE ANDROGEN RECEPTOR AND USES THEREOF | ESSA PHARMA, INC. (CA) | 2020-10-01 | — | — | WO | disclosed |
| US-4143047-A | 2-SULFINYL AND 2-SULFONYL OXAZOLES | LILLY INDUSTRIES LIMITED (GB) | 1979-03-06 | — | — | US | disclosed |