Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.77 |
| ▸ | USP2 | O75604 | 1/20 | 0.77 |
| ▸ | NPC1 | O15118 | 6/20 | 0.73 |
| ▸ | RAB9A | P51151 | 6/20 | 0.73 |
| ▸ | TP53 | P04637 | 5/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.69 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | GLA | P06280 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8267163 | 0.90 | SMN1; SMN2 (0.88) | SMN1; SMN2ALDH1A1USP2NPC1RAB9A | |
| SCHEMBL11533648 | 0.85 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1USP2NPC1RAB9A | |
| SCHEMBL10192041 | 0.85 | SMN1; SMN2 (0.76) | SMN1; SMN2ALDH1A1USP2NPC1RAB9A | |
| SCHEMBL20620013 | 0.84 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL8267293 | 0.84 | SMN1; SMN2 (0.74) | SMN1; SMN2ALDH1A1USP2NPC1RAB9A | |
| SCHEMBL8266868 | 0.83 | RAB9A (0.77) | SMN1; SMN2ALDH1A1USP2NPC1RAB9A | |
| SCHEMBL8267156 | 0.83 | SMN1; SMN2 (0.72) | SMN1; SMN2ALDH1A1USP2NPC1RAB9A | |
| SCHEMBL16486346 | 0.82 | NPC1 (1.00) | SMN1; SMN2ALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL8267173 | 0.81 | NPC1 (0.90) | SMN1; SMN2ALDH1A1USP2NPC1RAB9A | |
| SCHEMBL21695725 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1USP2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4137321-A | Isoxazole carboxamides of m-aminotetramisole as anthelmintics | PFIZER INC. (US) | 1979-01-30 | — | — | US | disclosed |