SCHEMBL11535682

SCHEMBL11535682

COc1ccc2c(c1)Nc1ccccc1O2

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 11/20 0.59
NOX1 Q9Y5S8 2/20 0.53
MAPT P10636 3/20 0.49
KMT2A Q03164 2/20 0.49
TDP1 Q9NUW8 2/20 0.49
L3MBTL1 Q9Y468 2/20 0.49
MEN1 O00255 1/20 0.49
LMNA P02545 1/20 0.49
GAA P10253 1/20 0.49
MAPK1 P28482 1/20 0.49
HTT P42858 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
KDM4E B2RXH2 1/20 0.46
POLB P06746 1/20 0.46
TRPA1 O75762 1/20 0.45
HTR7 P34969 1/20 0.43
HTR2B P41595 1/20 0.43
SNCA P37840 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31191638 1.00 ALOX5 (0.59) ALOX5NOX1MAPTKMT2ATDP1
SCHEMBL31191629 0.90 ALOX5 (0.59) ALOX5NOX1MAPTKMT2ATDP1
SCHEMBL21628231 0.90 ALOX5 (0.59) ALOX5NOX1MAPTKMT2ATDP1
SCHEMBL5739379 0.83 MAPT (0.52) ALOX5NOX1MAPTKMT2ATDP1
SCHEMBL1368163 0.82 MAPT (0.58) ALOX5MAPTKMT2ATDP1L3MBTL1
SCHEMBL9274293 0.82 MAPT (0.54) MAPTKMT2ATDP1L3MBTL1MEN1
SCHEMBL28435095 0.81 MAPT (0.65) ALOX5MAPTKMT2ATDP1L3MBTL1
SCHEMBL13461776 0.80 SNCA (0.55) ALOX5NOX1MAPTKMT2ATDP1
SCHEMBL34467599 0.80 SNCA (0.55) ALOX5NOX1MAPTKMT2ATDP1
SCHEMBL5739380 0.79 MAPT (0.73) ALOX5MAPTKMT2ATDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4132794-A 10-Imidoylacridan compositions MEAD JOHNSON & COMPANY (US) 1979-01-02 US disclosed
US-4115571-A DIURETICS, SMOOTH MUSCLE RELAXANTS, ANTITHROMBOGENIC AGENTS MEAD JOHNSON & COMPANY (US) 1978-09-19 US disclosed
US-4094981-A SMOOTH MUSCLE RELAXANT EMPLOYING 10-IMIDOYLACRIDANS MEAD JOHNSON & COMPANY (US) 1978-06-13 US disclosed
US-4077959-A DIURETICS, SMOOTH MUSCLE RELAXANTS, ANTITHROMBOGENIC MEAD JOHNSON & COMPANY (US) 1978-03-07 US disclosed
US-4046891-A Smooth muscle relaxant process employing 10-imidoylphenoxazines MEAD JOHNSON & COMPANY (US) 1977-09-06 US disclosed
US-3962252-A 10-IMIDOYLACRIDANS MEAD JOHNSON & COMPANY (US) 1976-06-08 US disclosed
US-3946004-A DIURETICS, MUSCLE RELAXANTS, ANTITHROMBOGENIC AGENTS MEAD JOHNSON & COMPANY (US) 1976-03-23 US disclosed