Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PYGL | P06737 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TSPO | P30536 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7135596 | 0.83 | NPC1 (0.73) | NPC1RAB9AKMT2ACA12CA9 | |
| SCHEMBL25139681 | 0.81 | MTNR1A (0.48) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20954579 | 0.81 | NPC1 (0.82) | NPC1RAB9AKMT2ACA12CA9 | |
| SCHEMBL8090586 | 0.81 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2ALDH1A1TSPO | |
| SCHEMBL11192974 | 0.79 | NPC1 (0.85) | NPC1RAB9AKMT2ACA12CA9 | |
| SCHEMBL5639645 | 0.79 | NPC1 (0.67) | NPC1RAB9AKMT2ACA12CA9 | |
| SCHEMBL5639640 | 0.79 | NPC1 (0.67) | NPC1RAB9AKMT2ACA12CA9 | |
| SCHEMBL14617669 | 0.77 | SMN1; SMN2 (0.68) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3163935 | 0.77 | NPC1 (0.75) | NPC1RAB9AKMT2ACA12CA9 | |
| SCHEMBL544272 | 0.77 | NPC1 (0.75) | NPC1RAB9AKMT2ACA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4150143-A | N-Substituted-acylamino-oxazoles as antiasthma agents | LILLY INDUSTRIES LIMITED (GB) | 1979-04-17 | — | — | US | disclosed |
| US-4122183-A | ANTIASTHMATIC | LILLY INDUSTRIES LIMITED (GB) | 1978-10-24 | — | — | US | disclosed |