Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | TSPO | P30536 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.46 |
| ▸ | RNF4 | P78317 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11537320 | 0.81 | NPC1 (0.69) | NPC1RAB9AALDH1A1SMN1; SMN2THRB | |
| SCHEMBL6631329 | 0.80 | AKT1 (0.54) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL12679649 | 0.78 | NPC1 (0.69) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL5804310 | 0.78 | ALDH1A1 (0.69) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL5694553 | 0.78 | TSPO (0.72) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL29904838 | 0.77 | NPC1 (0.67) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL9363123 | 0.77 | NPC1 (0.67) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL5144036 | 0.76 | ALDH1A1 (0.71) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL5144037 | 0.76 | NPC1 (0.71) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL5461474 | 0.76 | NPC1 (0.61) | NPC1RAB9AALDH1A1HTTPAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056446-A1 | ANTICONVULSANT DRUGS AND PHARMACEUTICAL COMPOSITIONS THEREOF | YISSUM RESEARCH AND DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2000-12-06 | — | — | EP | disclosed |
| US-6028102-A | Anticonvulsant drugs and pharmaceutical compositions thereof | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM | 2000-02-22 | — | — | US | disclosed |
| WO-1999043309-A2 | ANTICONVULSANT DRUGS AND PHARMACEUTICAL COMPOSITIONS THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY (IL) | 1999-09-02 | — | — | WO | disclosed |