Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | Q9HBH1 | 1/20 | 0.45 | |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11540900 | 0.86 | MAPT (0.52) | MAPTRAB9AKMT2APOLBHPGD | |
| SCHEMBL11540613 | 0.85 | MAPT (0.53) | MAPTRAB9APOLBHPGDHTT | |
| SCHEMBL11539862 | 0.85 | LMNA (0.46) | MAPTRAB9APOLBNPSR1HTT | |
| SCHEMBL11541053 | 0.84 | MAPT (0.42) | MAPTRAB9APOLBHPGDNPSR1 | |
| SCHEMBL11541423 | 0.83 | MAPT (0.59) | MAPTRAB9AHPGDNPSR1HTT | |
| SCHEMBL11543650 | 0.81 | SRD5A2 (0.47) | NPC1MAPTRAB9APOLBGAA | |
| SCHEMBL11538281 | 0.81 | CYP2C9 (0.55) | NPC1MAPTRAB9AKMT2APOLB | |
| SCHEMBL11578244 | 0.81 | NPC1 (0.60) | NPC1MAPTRAB9AKMT2APOLB | |
| SCHEMBL11256540 | 0.80 | RAB9A (0.59) | NPC1MAPTRAB9AKMT2APOLB | |
| SCHEMBL11540813 | 0.79 | MAPK1 (0.51) | MAPTPOLBHPGDNPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4166819-A | HYPOTENSIVES, DIURETICS | ABBOTT LABORATORIES (US) | 1979-09-04 | — | — | US | disclosed |
| US-4058559-A | HYPOTENSIVE AGENTS, DIURETICS, URICOSURIC AGENTS | ABBOTT LABORATORIES (US) | 1977-11-15 | — | — | US | disclosed |