Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.45 |
| ▸ | GABRE | P78334 | 1/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.45 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11370006 | 0.91 | LMNA (0.59) | LMNACHRM1TRPV1GABRA1GABRA5 | |
| SCHEMBL11370002 | 0.91 | LMNA (0.59) | LMNACHRM1TRPV1GABRA1GABRA5 | |
| SCHEMBL7318010 | 0.90 | GABRA1 (0.57) | LMNACHRM1GABRA1GABRA5GABRA3 | |
| SCHEMBL7308434 | 0.87 | LMNA (0.62) | LMNACHRM1TRPV1GABRA1GABRA5 | |
| SCHEMBL7308433 | 0.87 | LMNA (0.62) | LMNACHRM1TRPV1GABRA1GABRA5 | |
| Alcohol SCHEMBL7308836 | 0.87 | GABRA1 (0.53) | LMNACHRM1GABRA1GABRA5GABRA3 | |
| Alcohol SCHEMBL7308824 | 0.87 | GABRA1 (0.53) | LMNACHRM1GABRA1GABRA5GABRA3 | |
| SCHEMBL7320236 | 0.86 | LMNA (0.53) | LMNACHRM1TRPV1 | |
| SCHEMBL7310651 | 0.86 | LMNA (0.53) | LMNACHRM1TRPV1GABRA1GABRA5 | |
| SCHEMBL11364567 | 0.85 | LMNA (0.67) | LMNACHRM1TRPV1GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4166185-A | ANTICONVULSANTS, ANXIOLYTICS, SEDATIVES, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1979-08-28 | — | — | US | disclosed |
| US-4147875-A | ANTIDEPRESSANTS, ANTICONBULSANTS, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1979-04-03 | — | — | US | disclosed |
| US-4146722-A | SEDATIVES, MUSCLE RELAXANTS, ANTICONVULSANTS | HOFFMANN-LA ROCHE INC. (US) | 1979-03-27 | — | — | US | disclosed |
| US-4125726-A | SEDATIVES, MUSCLE RELAXANTS, ANXIOLYTICS, ANTICONVULSANTS | HOFFMANN-LA ROCHE INC. (US) | 1978-11-14 | — | — | US | disclosed |