Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7682737 | 0.82 | SMN1; SMN2 (0.50) | NPSR1SMN1; SMN2GPBAR1LMNAMLYCD | |
| SCHEMBL4402773 | 0.82 | SMN1; SMN2 (0.62) | RAB9AMEN1KMT2ANPSR1NR1H4 | |
| SCHEMBL27548961 | 0.80 | NR1H4 (0.50) | RAB9AMEN1KMT2ANPSR1NR1H4 | |
| SCHEMBL11620772 | 0.78 | SMN1; SMN2 (0.73) | NPSR1SMN1; SMN2LMNAMLYCDGAA | |
| SCHEMBL4403426 | 0.77 | NR1H4 (0.51) | RAB9AMEN1KMT2ANPSR1NR1H4 | |
| SCHEMBL760449 | 0.77 | NPSR1 (0.59) | RAB9AMEN1KMT2ANPSR1NR1H4 | |
| SCHEMBL8986913 | 0.77 | ALDH1A1 (0.48) | RAB9AMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL11616779 | 0.77 | ALDH1A1 (0.50) | RAB9AMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL24448783 | 0.76 | NPSR1 (0.58) | RAB9AMEN1KMT2ANPSR1NR1H4 | |
| SCHEMBL13227078 | 0.76 | NR1H4 (0.50) | RAB9AMEN1KMT2ANPSR1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4136180-A | HYPOLIPIDEMIC SUBSTITUTED STYRENESULFONYLUREAS | PFIZER INC. (US) | 1979-01-23 | — | — | US | disclosed |
| US-4062960-A | Hypolipidemic alkenesulfonamides | PFIZER INC. (US) | 1977-12-13 | — | — | US | disclosed |
| US-3983107-A | ARTERIOSCLEROSIS | PFIZER INC. (US) | 1976-09-28 | — | — | US | disclosed |