Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | FBP1 | P09467 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11539361 | 1.00 | PTGES2 (0.38) | PTGES2CNR1KDM4EALDH1A1LMNA | |
| SCHEMBL11537228 | 0.90 | KDM4E (0.39) | KDM4EALDH1A1LMNAMAPTTSHR | |
| SCHEMBL11537232 | 0.90 | KDM4E (0.39) | KDM4EALDH1A1LMNAMAPTTSHR | |
| SCHEMBL11540509 | 0.81 | CNR1 (0.35) | PTGES2CNR1KDM4EALDH1A1LMNA | |
| SCHEMBL11540515 | 0.81 | CNR1 (0.35) | PTGES2CNR1KDM4EALDH1A1LMNA | |
| SCHEMBL11538501 | 0.79 | KDM4E (0.40) | KDM4EALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL11544051 | 0.76 | PTGES2 (0.47) | PTGES2KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL11544054 | 0.76 | PTGES2 (0.47) | PTGES2KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL11540389 | 0.72 | KDM4E (0.40) | KDM4EALDH1A1TSHRSMN1; SMN2KMT2A | |
| SCHEMBL11540386 | 0.72 | KDM4E (0.40) | KDM4EALDH1A1TSHRSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4136180-A | HYPOLIPIDEMIC SUBSTITUTED STYRENESULFONYLUREAS | PFIZER INC. (US) | 1979-01-23 | — | — | US | disclosed |
| US-4062960-A | Hypolipidemic alkenesulfonamides | PFIZER INC. (US) | 1977-12-13 | — | — | US | disclosed |
| US-3983107-A | ARTERIOSCLEROSIS | PFIZER INC. (US) | 1976-09-28 | — | — | US | disclosed |