Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | APEX1 | P27695 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | HEXA | P06865 | 1/20 | 0.53 |
| ▸ | HEXB | P07686 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11538022 | 0.92 | KDM4E (0.54) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL25583428 | 0.90 | KDM4E (0.76) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL6896845 | 0.86 | ALDH1A1 (0.79) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL6896852 | 0.86 | ALDH1A1 (0.79) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL10898781 | 0.84 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL25583427 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL9665050 | 0.81 | ALDH1A1 (0.78) | ALDH1A1POLBKMT2AGAAMEN1 | |
| SCHEMBL29179696 | 0.80 | HEXA (0.57) | KDM4EALDH1A1HPGDHSD17B10HEXA | |
| SCHEMBL3851617 | 0.76 | POLB (0.58) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL5828001 | 0.76 | ALDH1A1 (0.68) | KDM4EALDH1A1HPGDHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4180579-A | 2-Substituted-1H-benz[de]-isoquinoline-1,3(2H)-diones | E. R. SQUIBB & SONS, INC. (US) | 1979-12-25 | — | — | US | disclosed |
| US-4170651-A | ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1979-10-09 | — | — | US | disclosed |
| US-4115555-A | ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-4051246-A | ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1977-09-27 | — | — | US | disclosed |