Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11540250 | 1.00 | CA1 (0.49) | CA1CA2CA4CA7TRPA1 | |
| SCHEMBL27514144 | 0.75 | TRPA1 (0.52) | CA1CA2CA4CA7TRPA1 | |
| SCHEMBL14198039 | 0.74 | TRPA1 (0.55) | CA1CA2CA4CA7TRPA1 | |
| SCHEMBL4619195 | 0.73 | AKR1C3 (0.50) | CA1CA2CA4CA7ALDH1A1 | |
| SCHEMBL5419434 | 0.73 | AKR1C3 (0.50) | CA1CA2CA4CA7ALDH1A1 | |
| SCHEMBL5418658 | 0.73 | AKR1C3 (0.50) | CA1CA2CA4CA7ALDH1A1 | |
| SCHEMBL10986325 | 0.72 | CA1 (0.47) | CA1CA2CA4CA7TRPA1 | |
| SCHEMBL11744871 | 0.72 | ALDH1A1 (0.53) | CA1CA2CA4CA7TRPA1 | |
| SCHEMBL11744877 | 0.72 | ALDH1A1 (0.53) | CA1CA2CA4CA7TRPA1 | |
| SCHEMBL16796582 | 0.70 | TRPA1 (0.52) | CA1CA2CA4CA7TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4136180-A | HYPOLIPIDEMIC SUBSTITUTED STYRENESULFONYLUREAS | PFIZER INC. (US) | 1979-01-23 | — | — | US | disclosed |
| US-4062960-A | Hypolipidemic alkenesulfonamides | PFIZER INC. (US) | 1977-12-13 | — | — | US | disclosed |
| US-3983107-A | ARTERIOSCLEROSIS | PFIZER INC. (US) | 1976-09-28 | — | — | US | disclosed |