Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11543847 | 0.92 | KDM4E (0.42) | ALDH1A1HSD17B10KDM4EUSP2HPGD | |
| SCHEMBL11548139 | 0.92 | ALDH1A1 (0.47) | ALDH1A1HSD17B10KDM4EUSP2HPGD | |
| SCHEMBL11543283 | 0.91 | KDM4E (0.40) | ALDH1A1HSD17B10KDM4EUSP2HPGD | |
| SCHEMBL11546423 | 0.90 | HPGD (0.43) | ALDH1A1HSD17B10KDM4EUSP2HPGD | |
| SCHEMBL11541774 | 0.86 | KDM4E (0.53) | ALDH1A1HSD17B10KDM4EUSP2HPGD | |
| SCHEMBL11547756 | 0.83 | ALDH1A1 (0.41) | ALDH1A1HSD17B10KDM4EUSP2HPGD | |
| SCHEMBL11541453 | 0.81 | ALDH1A1 (0.61) | ALDH1A1HSD17B10KDM4EUSP2HPGD | |
| SCHEMBL11542637 | 0.81 | ALDH1A1 (0.48) | ALDH1A1HSD17B10KDM4EUSP2HPGD | |
| SCHEMBL11547525 | 0.80 | ALDH1A1 (0.41) | ALDH1A1HSD17B10KDM4EUSP2HPGD | |
| SCHEMBL11548825 | 0.79 | ALDH1A1 (0.45) | ALDH1A1HSD17B10KDM4EUSP2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4161531-A | Diuretic and saluretic 5-sulfamoylbenzoic acid derivatives carrying a heterocyclic substituent | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-17 | — | — | US | disclosed |
| US-4118397-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |
| US-4111953-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |
| US-4093735-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-06-06 | — | — | US | disclosed |