Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 14/20 | 0.37 |
| ▸ | CA1 | P00915 | 13/20 | 0.37 |
| ▸ | CA9 | Q16790 | 11/20 | 0.37 |
| ▸ | CA4 | P22748 | 7/20 | 0.37 |
| ▸ | CA12 | O43570 | 6/20 | 0.37 |
| ▸ | CA7 | P43166 | 4/20 | 0.37 |
| ▸ | CA13 | Q8N1Q1 | 4/20 | 0.37 |
| ▸ | CA6 | P23280 | 3/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11548139 | 0.87 | ALDH1A1 (0.47) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11546144 | 0.85 | KDM4E (0.61) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11545196 | 0.84 | KDM4E (0.60) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11552445 | 0.82 | KDM4E (0.45) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11544486 | 0.79 | ALDH1A1 (0.41) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11543847 | 0.79 | KDM4E (0.42) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11543283 | 0.79 | KDM4E (0.40) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11541774 | 0.78 | KDM4E (0.53) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11545133 | 0.78 | ALDH1A1 (0.74) | ALDH1A1KDM4ELMNAUSP2HPGD | |
| SCHEMBL11546423 | 0.77 | HPGD (0.43) | ALDH1A1KDM4ELMNAUSP2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4161531-A | Diuretic and saluretic 5-sulfamoylbenzoic acid derivatives carrying a heterocyclic substituent | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-17 | — | — | US | disclosed |
| US-4118397-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |
| US-4111953-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |
| US-4093735-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-06-06 | — | — | US | disclosed |
| US-4010273-A | DIURETICS, SALURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-03-01 | — | — | US | disclosed |