Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | USP2 | O75604 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.68 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MYC | P01106 | 9/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11546942 | 0.83 | LMNA (0.91) | HSD17B10KDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL2741894 | 0.83 | HSD17B10 (0.71) | HSD17B10KDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL2741893 | 0.82 | KDM4E (0.62) | HSD17B10KDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL11548130 | 0.82 | LMNA (0.80) | HSD17B10KDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL10998669 | 0.81 | ALDH1A1 (0.65) | HSD17B10KDM4EUSP2ALDH1A1LMNA | |
| Piretanide SCHEMBL30230376 | 0.81 | KDM4E (1.00) | HSD17B10KDM4EUSP2ALDH1A1LMNA | |
| Piretanide SCHEMBL49473 | 0.81 | KDM4E (1.00) | HSD17B10KDM4EUSP2ALDH1A1LMNA | |
| Piretanide SCHEMBL1741994 | 0.81 | KDM4E (1.00) | HSD17B10KDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL11542770 | 0.81 | KDM4E (0.95) | HSD17B10KDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL10998437 | 0.81 | ALDH1A1 (0.67) | HSD17B10KDM4EUSP2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4176190-A | Diuretic and saliuretic sulphamoylbenzoic acids | CIBA-GEIGY CORPORATION (US) | 1979-11-27 | — | — | US | disclosed |