Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.50 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.50 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11545991 | 0.89 | NAMPT (0.61) | NAMPTSLC6A7MEN1KMT2APDGFRB | |
| SCHEMBL11542771 | 0.88 | NAMPT (0.48) | NAMPTSLC6A7MAPTMEN1CYP1A2 | |
| SCHEMBL11540798 | 0.88 | MAPT (0.51) | NAMPTSLC6A7MAPTMEN1CYP1A2 | |
| SCHEMBL11542920 | 0.87 | MAPT (0.57) | NAMPTSLC6A7MAPTMEN1CYP1A2 | |
| SCHEMBL11543276 | 0.86 | MEN1 (0.47) | NAMPTSLC6A7MAPTMEN1CYP1A2 | |
| SCHEMBL11542231 | 0.86 | SLC6A7 (0.60) | NAMPTSLC6A7CYP2C9MAPKAPK2PDGFRB | |
| SCHEMBL11542080 | 0.86 | NAMPT (0.46) | NAMPTSLC6A7MAPTMEN1CYP1A2 | |
| SCHEMBL11544535 | 0.86 | NAMPT (0.46) | NAMPTSLC6A7MAPTMEN1CYP1A2 | |
| SCHEMBL11543456 | 0.86 | NAMPT (0.46) | NAMPTSLC6A7MAPTMEN1CYP1A2 | |
| SCHEMBL7346130 | 0.85 | PDGFRB (0.51) | NAMPTPRKD3MAP4K4KDRGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4167567-A | Antihypertensive 4-aminoquinolines | THE UPJOHN COMPANY (US) | 1979-09-11 | — | — | US | claimed |
| US-4167567-A | Antihypertensive 4-aminoquinolines | THE UPJOHN COMPANY (US) | 1979-09-11 | — | — | US | disclosed |