Azaconazole

Azaconazole

SCHEMBL11544952

Clc1ccc(C2(Cn3cncn3)OCCO2)c(Cl)c1.O=S(=O)(O)O

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Azaconazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 1/20 0.46
ADRA2A known ✓ P08913 1/20 0.46
CHRM1 known ✓ P11229 1/20 0.46
ADRA2B known ✓ P18089 1/20 0.46
ADRA2C known ✓ P18825 1/20 0.46
CHRM3 known ✓ P20309 1/20 0.46
SLC6A2 known ✓ P23975 1/20 0.46
ADRA1D known ✓ P25100 1/20 0.46
ADRA1A known ✓ P35348 1/20 0.46
SLC6A3 known ✓ Q01959 1/20 0.46
CYP3A4 P08684 15/20 0.61
THRB P10828 1/20 0.61
CYP2C9 P11712 2/20 0.54
KDM4E B2RXH2 1/20 0.48
LMNA P02545 3/20 0.46
FYN P06241 2/20 0.46
CYP51A1 Q16850 2/20 0.46
NR1I2 O75469 1/20 0.46
PGR P06401 1/20 0.46
HSP90AA1 P07900 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Azaconazole SCHEMBL21056 0.93 CYP3A4 (0.69) CYP3A4THRBCYP2C9KDM4ELMNA
Azaconazole SCHEMBL29354903 0.93 CYP3A4 (0.69) CYP3A4THRBCYP2C9KDM4ELMNA
Azaconazole SCHEMBL3009257 0.93 CYP3A4 (0.69) CYP3A4THRBCYP2C9KDM4ELMNA
Azaconazole SCHEMBL29017725 0.92 CYP3A4 (0.67) CYP3A4THRBCYP2C9KDM4ELMNA
Azaconazole SCHEMBL11543267 0.89 KDM4E (0.60) CYP3A4THRBCYP2C9KDM4ELMNA
SCHEMBL2127240 0.89 CYP3A4 (0.66) CYP3A4THRBCYP2C9KDM4ELMNA
Azaconazole SCHEMBL10712944 0.85 CYP3A4 (0.57) CYP3A4THRBCYP2C9KDM4ELMNA
SCHEMBL11540746 0.83 CYP3A4 (0.56) CYP3A4THRBCYP2C9KDM4ELMNA
SCHEMBL10512062 0.83 CYP3A4 (0.64) CYP3A4THRBCYP2C9KDM4ELMNA
SCHEMBL10622412 0.83 CYP3A4 (0.80) CYP3A4THRBCYP2C9KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108929207-B Synthetic method of penconazole intermediate 齐鲁师范学院 2022-01-18 CN disclosed
CN-111601802-A Heterocyclic compounds as pesticides 拜耳股份有限公司 2020-08-28 CN disclosed
US-4160838-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1979-07-10 US disclosed
US-4079062-A ANTIMICROBIAL, PLANT GROWTH REGULATORS; 1-(B-ARYL)ETHYL-1H-1,2,4-TRIAZOLE KETALS JANSSEN PHARMACEUTICA N.V. (BE) 1978-03-14 US disclosed