Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | USP2 | O75604 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.73 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | AQP1 | P29972 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11543884 | 0.92 | KDM4E (0.61) | LMNAKDM4EUSP2ALDH1A1HPGD | |
| SCHEMBL11546942 | 0.87 | LMNA (0.91) | LMNAKDM4EUSP2ALDH1A1HPGD | |
| Piretanide SCHEMBL1741994 | 0.85 | KDM4E (1.00) | LMNAKDM4EUSP2ALDH1A1HPGD | |
| Piretanide SCHEMBL49473 | 0.85 | KDM4E (1.00) | LMNAKDM4EUSP2ALDH1A1HPGD | |
| SCHEMBL11542770 | 0.85 | KDM4E (0.95) | LMNAKDM4EUSP2ALDH1A1HPGD | |
| Piretanide SCHEMBL30230376 | 0.85 | KDM4E (1.00) | LMNAKDM4EUSP2ALDH1A1HPGD | |
| Piretanide SCHEMBL9837127 | 0.84 | KDM4E (0.98) | LMNAKDM4EUSP2ALDH1A1HPGD | |
| SCHEMBL2741891 | 0.84 | KDM4E (0.98) | LMNAKDM4EUSP2ALDH1A1HPGD | |
| SCHEMBL11548130 | 0.83 | LMNA (0.80) | LMNAKDM4EUSP2ALDH1A1HPGD | |
| Piretanide SCHEMBL18075706 | 0.83 | KDM4E (0.95) | LMNAKDM4EUSP2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4161531-A | Diuretic and saluretic 5-sulfamoylbenzoic acid derivatives carrying a heterocyclic substituent | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-17 | — | — | US | disclosed |
| US-4118397-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |
| US-4111953-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |
| US-4093735-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-06-06 | — | — | US | disclosed |
| US-4010273-A | DIURETICS, SALURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-03-01 | — | — | US | disclosed |