Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.98 |
| ▸ | HPGD | P15428 | 3/20 | 0.98 |
| ▸ | USP2 | O75604 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.98 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piretanide SCHEMBL1741994 | 0.99 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| Piretanide SCHEMBL30230376 | 0.99 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| Piretanide SCHEMBL49473 | 0.99 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| SCHEMBL2741891 | 0.98 | KDM4E (0.98) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| Piretanide SCHEMBL18075706 | 0.97 | KDM4E (0.95) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| Piretanide SCHEMBL7895002 | 0.97 | KDM4E (0.95) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| SCHEMBL11542770 | 0.96 | KDM4E (0.95) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| SCHEMBL11546942 | 0.94 | LMNA (0.91) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| SCHEMBL231996 | 0.91 | ALDH1A1 (0.85) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| Piretanide SCHEMBL250849 | 0.91 | KDM4E (0.84) | KDM4EHSD17B10ALDH1A1HPGDUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243891-B1 | A LAMINAR STRUCTURE FOR ADMINISTERING A CHEMICAL AT A CONTROLLED RELEASE RATE | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-08-14 | — | — | EP | disclosed |
| US-4931281-A | Laminar structure for administering a chemical at a controlled release rate | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-05 | — | — | US | disclosed |
| EP-0243891-A2 | A laminar structure for administering a chemical at a controlled release rate | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1987-11-04 | — | — | EP | disclosed |