Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 5/20 | 0.56 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11543497 | 0.85 | NR4A2 (0.59) | NR4A2NR4A1NR4A3KMT2AMEN1 | |
| SCHEMBL11546746 | 0.85 | NPC1 (0.54) | NR4A2KMT2AMEN1NPC1RAB9A | |
| SCHEMBL11545859 | 0.85 | NR4A2 (0.64) | NR4A2NR4A1NR4A3KMT2AMEN1 | |
| SCHEMBL11573595 | 0.82 | BACE1 (0.47) | KMT2AMEN1TAAR1NPC1RAB9A | |
| SCHEMBL11545984 | 0.81 | KDM4E (0.52) | KMT2AMEN1TAAR1NPC1RAB9A | |
| SCHEMBL9741522 | 0.80 | NR4A2 (0.61) | NR4A2NR4A1NR4A3KMT2ANPC1 | |
| SCHEMBL11544924 | 0.79 | NR4A2 (0.56) | NR4A2NR4A1NR4A3KMT2AMEN1 | |
| SCHEMBL5476778 | 0.78 | NPC1 (0.68) | KMT2AMEN1NPC1RAB9ABACE1 | |
| SCHEMBL9770455 | 0.78 | BACE1 (0.58) | KMT2ANPC1RAB9ABACE1 | |
| SCHEMBL9770526 | 0.77 | BACE1 (0.52) | BACE1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4144351-A | ANTICHOLESTEROL | KLINGE PHARMA GMBH & CO. (DE) | 1979-03-13 | — | — | US | disclosed |
| US-4109013-A | SUBSTITUTED PROPANOL-(2) DERIVATIVES OF HYDROXAMIC ACIDS AND THE USE THEREOF AS HYPOLIPEMIC DRUGS | KLINGE PHARMA GMBH & CO. (DE) | 1978-08-22 | — | — | US | disclosed |
| US-4073935-A | Substituted propanol-(2)-derivatives and their nicotinic acid esters, and process for their preparation, and the use thereof as hypolipemic drugs | KLINGE PHARMA GMBH & CO. (DT) | 1978-02-14 | — | — | US | disclosed |