Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.45 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11548757 | 0.84 | BACE1 (0.56) | SMN1; SMN2P2RX7MEN1ALDH1A1LMNA | |
| SCHEMBL11546525 | 0.80 | NLRP3 (0.49) | SMN1; SMN2MEN1ALDH1A1KMT2ANPSR1 | |
| SCHEMBL11552737 | 0.79 | GSK3B (0.42) | MEN1ALDH1A1MAPTKMT2ARAB9A | |
| SCHEMBL1160190 | 0.79 | POLB (0.61) | SMN1; SMN2ALDH1A1MAPTKMT2AMGLL | |
| SCHEMBL4066082 | 0.78 | MGLL (0.65) | SMN1; SMN2ALDH1A1MAPTMGLLNPC1 | |
| SCHEMBL11546203 | 0.77 | HPGD (0.44) | SMN1; SMN2MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL11549836 | 0.76 | HPGD (0.39) | SMN1; SMN2ALDH1A1LMNANPSR1NPC1 | |
| SCHEMBL11547089 | 0.76 | KMT2A (0.51) | SMN1; SMN2MEN1LMNAMAPTKMT2A | |
| SCHEMBL872000 | 0.74 | NPC1 (0.55) | SMN1; SMN2P2RX7OPRK1MGLLNPC1 | |
| SCHEMBL16755148 | 0.73 | GCK (0.50) | SMN1; SMN2MEN1MAPTKMT2AMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4145363-A | ANTIASTHMATICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1979-03-20 | — | — | US | disclosed |
| US-4063025-A | PROPHYLAXIS, ANTIASTHMATIC | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JA) | 1977-12-13 | — | — | US | disclosed |