SCHEMBL11545296

SCHEMBL11545296

O=C(O)c1ccc(C=Cc2ccc(C=Cc3ccccc3)cc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.67
ALDH1A1 P00352 2/20 0.60
TSHR P16473 2/20 0.59
DAO P14920 1/20 0.59
NAPRT Q6XQN6 1/20 0.59
SRD5A2 P31213 2/20 0.59
SRD5A1 P18405 1/20 0.59
TTR P02766 2/20 0.58
TP53 P04637 1/20 0.57
CA1 P00915 1/20 0.57
CA2 P00918 1/20 0.57
FBP1 P09467 1/20 0.57
CES2 O00748 1/20 0.56
CES1 P23141 1/20 0.56
KMT2A Q03164 2/20 0.56
PTPN1 P18031 1/20 0.55
HNF4A P41235 1/20 0.55
NPC1 O15118 1/20 0.54
GAA P10253 1/20 0.54
MAPK1 P28482 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1927732 1.00 HDAC1 (0.67) HDAC1ALDH1A1TSHRDAONAPRT
SCHEMBL8437189 1.00 HDAC1 (0.67) HDAC1ALDH1A1TSHRDAONAPRT
SCHEMBL1927729 1.00 HDAC1 (0.67) HDAC1ALDH1A1TSHRDAONAPRT
Hydrochloric Acid SCHEMBL4353116 0.98 HDAC1 (0.64) HDAC1ALDH1A1TSHRDAONAPRT
SCHEMBL4364948 0.94 HDAC1 (0.60) HDAC1ALDH1A1TSHRDAONAPRT
Cyanide SCHEMBL11191586 0.94 HDAC1 (0.60) HDAC1ALDH1A1TSHRDAONAPRT
(Z)-1,2-Diphenylethene SCHEMBL18050254 0.93 TSHR (0.70) HDAC1ALDH1A1TSHRDAONAPRT
(Z)-1,2-Diphenylethene SCHEMBL29118837 0.93 TSHR (0.70) HDAC1ALDH1A1TSHRDAONAPRT
SCHEMBL9681086 0.93 ALDH1A1 (0.68) HDAC1ALDH1A1TSHRDAONAPRT
SCHEMBL69167 0.93 ALDH1A1 (0.68) HDAC1ALDH1A1TSHRDAONAPRT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4158099-A FROM SCHIFF BASES AND BIPHENYL COMPOUND CIBA-GEIGY AG (CH) 1979-06-12 US disclosed
US-3991049-A Aromatic compounds containing ethylene double bonds, processes for their manufacture and use CIBA-GEIGY AG (CH) 1976-11-09 US disclosed