SCHEMBL11546147

SCHEMBL11546147

CCCCCC(O)CCCC(CCCc1ccc(C(=O)OC)cc1)C(C)=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP4A11 Q02928 2/20 0.50
CYP4F2 P78329 1/20 0.49
MMP2 P08253 1/20 0.46
MMP3 P08254 1/20 0.46
MAPT P10636 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
TRPV1 Q8NER1 1/20 0.43
THRA P10827 1/20 0.41
THRB P10828 1/20 0.41
S1PR2 O95136 1/20 0.41
S1PR4 O95977 1/20 0.41
S1PR1 P21453 1/20 0.41
S1PR3 Q99500 1/20 0.41
HTR1A P08908 1/20 0.41
PLK1 P53350 1/20 0.41
PTGER4 P35408 3/20 0.41
PTGER2 P43116 3/20 0.41
LOXL2 Q9Y4K0 1/20 0.40
SPHK1 Q9NYA1 1/20 0.40
RARB P10826 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11549509 0.86 RARB (0.56) MMP2MMP3MAPTSMN1; SMN2TRPV1
SCHEMBL11549274 0.86 RARB (0.56) MMP2MMP3MAPTSMN1; SMN2TRPV1
SCHEMBL11546230 0.86 RARB (0.56) MMP2MMP3MAPTSMN1; SMN2TRPV1
SCHEMBL11551479 0.86 PLK1 (0.47) TRPV1THRATHRBPLK1PTGER4
SCHEMBL11547639 0.85 RARB (0.57) MAPTTRPV1THRATHRBPTGER4
SCHEMBL11548650 0.82 CTSK (0.37) MMP2MMP3TRPV1THRATHRB
SCHEMBL11548657 0.82 CTSK (0.37) MMP2MMP3TRPV1THRATHRB
SCHEMBL11548375 0.79 TMEM97 (0.47) TRPV1THRATHRBPLK1
SCHEMBL8044139 0.79 CYP4A11 (0.75) CYP4A11CYP4F2MAPTSMN1; SMN2THRA
SCHEMBL11632403 0.78 CYP4A11 (0.47) CYP4A11CYP4F2MMP2MMP3MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4150235-A ANTIBODY INHIBITORS, HYPOTENSIVE AGENTS, DIURETICS, VASODILATOR MERCK & CO., INC. (US) 1979-04-17 US claimed
US-4175203-A TREATMENT OF RENAL FAILURE AND TRANSPLANT REJECTION VASODILATORS MERCK & CO., INC. (US) 1979-11-20 US disclosed
US-4150235-A ANTIBODY INHIBITORS, HYPOTENSIVE AGENTS, DIURETICS, VASODILATOR MERCK & CO., INC. (US) 1979-04-17 US disclosed
US-4140861-A RENAL DISFUNCTION, ANTIBODY INHIBITORS MERCK & CO., INC. (US) 1979-02-20 US disclosed