Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.36 |
| ▸ | MMP2 | P08253 | 5/20 | 0.35 |
| ▸ | MMP3 | P08254 | 3/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 4/20 | 0.34 |
| ▸ | THRB | P10828 | 4/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11548650 | 1.00 | CTSK (0.37) | CTSKPTGER4PTGER2MMP2MMP3 | |
| SCHEMBL11546147 | 0.82 | CYP4A11 (0.50) | PTGER4PTGER2MMP2MMP3SPHK1 | |
| SCHEMBL11616886 | 0.78 | FFAR4 (0.40) | CTSK | |
| SCHEMBL11616881 | 0.78 | FFAR4 (0.40) | CTSK | |
| SCHEMBL11549274 | 0.76 | RARB (0.56) | PTGER4PTGER2MMP2MMP3TRPV1 | |
| SCHEMBL11546230 | 0.76 | RARB (0.56) | PTGER4PTGER2MMP2MMP3TRPV1 | |
| SCHEMBL11549509 | 0.76 | RARB (0.56) | PTGER4PTGER2MMP2MMP3TRPV1 | |
| SCHEMBL11551479 | 0.76 | PLK1 (0.47) | PTGER4PTGER2SPHK1TRPV1THRA | |
| SCHEMBL11547639 | 0.75 | RARB (0.57) | PTGER4PTGER2TRPV1THRATHRB | |
| SCHEMBL11750324 | 0.71 | FFAR4 (0.39) | CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4175203-A | TREATMENT OF RENAL FAILURE AND TRANSPLANT REJECTION VASODILATORS | MERCK & CO., INC. (US) | 1979-11-20 | — | — | US | disclosed |
| US-4150235-A | ANTIBODY INHIBITORS, HYPOTENSIVE AGENTS, DIURETICS, VASODILATOR | MERCK & CO., INC. (US) | 1979-04-17 | — | — | US | disclosed |
| US-4140861-A | RENAL DISFUNCTION, ANTIBODY INHIBITORS | MERCK & CO., INC. (US) | 1979-02-20 | — | — | US | disclosed |