Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4988306 | 0.86 | TSHR (0.41) | SMN1; SMN2TSHRGAAKDM4EKMT2A | |
| SCHEMBL4988588 | 0.81 | NAMPT (0.49) | KDM4ECYP1A2CYP3A4L3MBTL1LMNA | |
| SCHEMBL2066474 | 0.80 | NPSR1 (0.47) | SMN1; SMN2KDM4ECYP1A2CYP2C19CYP3A4 | |
| SCHEMBL1854440 | 0.77 | LMNA (0.43) | SMN1; SMN2KDM4ELMNAHPGD | |
| SCHEMBL3425959 | 0.76 | NPC1 (0.46) | SMN1; SMN2TSHRGAAKDM4ECYP1A2 | |
| SCHEMBL10654212 | 0.72 | KMT2A (0.62) | TSHRGAALMNAKMT2APOLB | |
| SCHEMBL9315850 | 0.71 | TSHR (0.47) | SMN1; SMN2TSHRGAAALOX15KDM4E | |
| SCHEMBL5776970 | 0.70 | NAMPT (0.58) | SMN1; SMN2TSHRGAACYP3A4L3MBTL1 | |
| SCHEMBL2875121 | 0.70 | CYP1A2 (0.47) | SMN1; SMN2TSHRGAAKDM4ECYP1A2 | |
| SCHEMBL1234999 | 0.70 | CYP4F2 (0.39) | SMN1; SMN2GAAALOX15KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4139623-A | HYPOTENSIVE AGENTS | C-G CORP. (US) | 1979-02-13 | — | — | US | disclosed |
| US-4027027-A | BETA-RECEPTOR-BLOCKERS, HYPOTENSIVES AND VALODILATORS; FOR TREATING ARRYTHMIAS AND ANGINA PECTORIS | CIBA-GEIGY CORPORATION (US) | 1977-05-31 | — | — | US | disclosed |