SCHEMBL11546404

SCHEMBL11546404

CC(C)(C)C(=O)C(Br)Oc1ccc(-c2ccc(Cl)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.48
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
ADORA3 P0DMS8 1/20 0.48
CHRM1 P11229 1/20 0.48
SLC6A2 P23975 1/20 0.48
SLC6A4 P31645 1/20 0.48
ADRA1A P35348 1/20 0.48
SLC6A3 Q01959 1/20 0.48
PPARA Q07869 8/20 0.43
PPARG P37231 6/20 0.43
CYP1A2 P05177 4/20 0.42
CYP2C19 P33261 3/20 0.42
CYP2D6 P10635 1/20 0.42
MAPT P10636 1/20 0.42
ELANE P08246 1/20 0.42
MAP4K4 O95819 2/20 0.39
GAA P10253 2/20 0.39
NPSR1 Q6W5P4 1/20 0.39
GPR55 Q9Y2T6 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8496952 0.95 CYP3A4 (0.51) CYP3A4MEN1KMT2AADORA3CHRM1
SCHEMBL11396758 0.87 OPRK1 (0.47) CYP3A4MEN1KMT2AADORA3CHRM1
SCHEMBL11393119 0.85 PPARA (0.43) CYP3A4MEN1KMT2AADORA3CHRM1
SCHEMBL11854999 0.83 CYP3A4 (0.52) CYP3A4MEN1KMT2AADORA3CHRM1
SCHEMBL11005515 0.82 PPARA (0.48) CYP3A4MEN1KMT2APPARAPPARG
SCHEMBL11277557 0.82 PPARA (0.53) CYP3A4MEN1KMT2AADORA3CHRM1
SCHEMBL11274755 0.82 PPARA (0.41) CYP3A4MEN1KMT2AADORA3CHRM1
SCHEMBL10827183 0.81 PPARA (0.58) CYP3A4MEN1KMT2AADORA3SLC6A2
SCHEMBL11268638 0.81 PPARA (0.50) CYP3A4MEN1KMT2AADORA3CHRM1
SCHEMBL11003522 0.81 PPARA (0.42) CYP3A4MEN1KMT2AADORA3CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4151287-A Combating fungi with 1-diaryloxy-1-triazolyl-3,3-dimethyl-butan-2-ones and butan-2-ols BAYER AKTIENGESELLSCHAFT (DE) 1979-04-24 US disclosed