Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.73 |
| ▸ | GAA | P10253 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | RXRA | P19793 | 1/20 | 0.55 |
| ▸ | RXRB | P28702 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.49 |
| ▸ | RARB | P10826 | 1/20 | 0.49 |
| ▸ | RARG | P13631 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terbufibrol SCHEMBL2733943 | 0.87 | NR4A2 (0.67) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL11545820 | 0.86 | HIF1A (0.62) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL11544838 | 0.86 | MAPT (0.61) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL11666560 | 0.84 | MAPT (0.67) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL11576822 | 0.84 | MAPT (0.67) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL11548347 | 0.84 | MAPT (0.61) | MAPTGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL11546865 | 0.84 | MAPT (0.61) | MAPTGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL11545891 | 0.83 | MAPT (0.66) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL11545760 | 0.83 | MAPT (0.66) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL11545950 | 0.80 | MAPT (0.68) | MAPTGAAALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4144351-A | ANTICHOLESTEROL | KLINGE PHARMA GMBH & CO. (DE) | 1979-03-13 | — | — | US | disclosed |
| US-4109013-A | SUBSTITUTED PROPANOL-(2) DERIVATIVES OF HYDROXAMIC ACIDS AND THE USE THEREOF AS HYPOLIPEMIC DRUGS | KLINGE PHARMA GMBH & CO. (DE) | 1978-08-22 | — | — | US | disclosed |
| US-4073935-A | Substituted propanol-(2)-derivatives and their nicotinic acid esters, and process for their preparation, and the use thereof as hypolipemic drugs | KLINGE PHARMA GMBH & CO. (DT) | 1978-02-14 | — | — | US | disclosed |