Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11545760 | 0.90 | MAPT (0.66) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL11545891 | 0.90 | MAPT (0.66) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL11547431 | 0.80 | MAPT (0.73) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL11551464 | 0.78 | MAPT (0.55) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL11544902 | 0.78 | MAPT (0.55) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL11619433 | 0.78 | LMNA (0.48) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL11543976 | 0.78 | CYP1A2 (0.51) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL8750844 | 0.78 | CA12 (0.53) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL846210 | 0.77 | CYP1A2 (0.68) | MAPTGAAALDH1A1LMNAKDM4E | |
| SCHEMBL846211 | 0.77 | CYP1A2 (0.68) | MAPTGAAALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4144351-A | ANTICHOLESTEROL | KLINGE PHARMA GMBH & CO. (DE) | 1979-03-13 | — | — | US | disclosed |
| US-4109013-A | SUBSTITUTED PROPANOL-(2) DERIVATIVES OF HYDROXAMIC ACIDS AND THE USE THEREOF AS HYPOLIPEMIC DRUGS | KLINGE PHARMA GMBH & CO. (DE) | 1978-08-22 | — | — | US | disclosed |
| US-4073935-A | Substituted propanol-(2)-derivatives and their nicotinic acid esters, and process for their preparation, and the use thereof as hypolipemic drugs | KLINGE PHARMA GMBH & CO. (DT) | 1978-02-14 | — | — | US | disclosed |