Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11546865 | 1.00 | MAPT (0.61) | MAPTHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL10950578 | 0.88 | MAPT (0.61) | MAPTHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL11546333 | 0.86 | CYP1A2 (0.65) | MAPTMEN1KMT2ANR4A2MAPK1 | |
| SCHEMBL9335724 | 0.86 | NR4A2 (0.51) | MAPTHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL11544924 | 0.85 | NR4A2 (0.56) | MAPTHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL11549983 | 0.85 | PPARA (0.61) | MAPTHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL11450956 | 0.85 | MAPT (0.85) | MAPTHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9339129 | 0.84 | NR4A2 (0.49) | MAPTMEN1KMT2ANR4A2MAPK1 | |
| SCHEMBL11547431 | 0.84 | MAPT (0.73) | MAPTHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL10950575 | 0.83 | KMT2A (0.53) | MAPTHTTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4144351-A | ANTICHOLESTEROL | KLINGE PHARMA GMBH & CO. (DE) | 1979-03-13 | — | — | US | disclosed |
| US-4109013-A | SUBSTITUTED PROPANOL-(2) DERIVATIVES OF HYDROXAMIC ACIDS AND THE USE THEREOF AS HYPOLIPEMIC DRUGS | KLINGE PHARMA GMBH & CO. (DE) | 1978-08-22 | — | — | US | disclosed |
| US-4073935-A | Substituted propanol-(2)-derivatives and their nicotinic acid esters, and process for their preparation, and the use thereof as hypolipemic drugs | KLINGE PHARMA GMBH & CO. (DT) | 1978-02-14 | — | — | US | disclosed |