Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | PTAFR | P25105 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | PLA2G2C | Q5R387 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | GLS2 | Q9UI32 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1982633 | 0.88 | PRKCA (0.45) | PRKCAADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL10698426 | 0.87 | PRKCA (0.49) | PRKCAADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL11547563 | 0.87 | PRKCA (0.41) | PRKCAADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL3841407 | 0.84 | PRKCA (0.39) | PRKCACYP1A2GLS2 | |
| Ether SCHEMBL9615792 | 0.84 | PRKCA (0.42) | PRKCAADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL11654945 | 0.82 | PRKCA (0.49) | PRKCAALDH1A1HSD17B10GLS2 | |
| SCHEMBL4328590 | 0.82 | PRKCA (0.57) | PRKCAADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL11654951 | 0.82 | PRKCA (0.49) | PRKCAALDH1A1HSD17B10GLS2 | |
| SCHEMBL11546492 | 0.82 | PLA2G2C (0.45) | PRKCAADRA1DPTAFRHTR1DHTR2C | |
| SCHEMBL1665609 | 0.79 | PRKCA (0.53) | PRKCAADRA1DPTAFRHTR1DHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4175203-A | TREATMENT OF RENAL FAILURE AND TRANSPLANT REJECTION VASODILATORS | MERCK & CO., INC. (US) | 1979-11-20 | — | — | US | disclosed |
| US-4150235-A | ANTIBODY INHIBITORS, HYPOTENSIVE AGENTS, DIURETICS, VASODILATOR | MERCK & CO., INC. (US) | 1979-04-17 | — | — | US | disclosed |
| US-4140861-A | RENAL DISFUNCTION, ANTIBODY INHIBITORS | MERCK & CO., INC. (US) | 1979-02-20 | — | — | US | disclosed |