Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 11/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11544932 | 0.89 | ACE (0.46) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL11550932 | 0.85 | ACE (0.58) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL6788316 | 0.83 | ACE (0.62) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL6788307 | 0.83 | ACE (0.62) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL10020477 | 0.80 | ACE (0.45) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL11547640 | 0.80 | ACE (0.58) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL7373956 | 0.80 | KMT2A (0.65) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL5742195 | 0.79 | SMN1; SMN2 (0.52) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL5742191 | 0.79 | SMN1; SMN2 (0.52) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL11244592 | 0.79 | SLC6A1 (0.54) | ACECHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154840-A | Antihypertensive pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |