Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11548414 | 0.89 | ACE (0.52) | ACEALDH1A1SMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL6788316 | 0.80 | ACE (0.62) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL6788307 | 0.80 | ACE (0.62) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL11547486 | 0.79 | ACE (0.44) | ACEDPP4SMN1; SMN2REN | |
| SCHEMBL11546483 | 0.77 | ACE (0.55) | ACELMNARAB9ACHRM2CHRM4 | |
| SCHEMBL11550932 | 0.77 | ACE (0.58) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL11547220 | 0.76 | NPC1 (0.59) | ACEALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL11544959 | 0.75 | DPP4 (0.49) | ACEALDH1A1HPGDDPP4NPC1 | |
| SCHEMBL11545865 | 0.75 | ACE (0.56) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL9392065 | 0.75 | ALDH1A1 (0.60) | ACEALDH1A1LMNARAB9AREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154840-A | Antihypertensive pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |