Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11547286 | 0.83 | TNF (0.38) | KDM4EHDAC6PDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL11547406 | 0.76 | PMP22 (0.52) | SMN1; SMN2KDM4EPDE4APDE4D | |
| SCHEMBL9873229 | 0.75 | NPC1 (0.41) | SMN1; SMN2KDM4EALDH1A1PDE10ATNF | |
| SCHEMBL24391579 | 0.73 | TNF (0.32) | SMN1; SMN2PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL4873272 | 0.67 | HDAC6 (0.68) | SMN1; SMN2HDAC6ALDH1A1TNF | |
| SCHEMBL8596166 | 0.66 | PDE10A (0.41) | SMN1; SMN2KDM4EALDH1A1HPGDPDE10A | |
| SCHEMBL11550575 | 0.66 | TNF (0.38) | SMN1; SMN2PDE3BPDE3AKDM4EHDAC6 | |
| SCHEMBL14942258 | 0.66 | TNF (0.46) | PDE3BPDE3AHDAC6PDE4APDE4B | |
| SCHEMBL24076916 | 0.66 | LMNA (0.42) | KDM4EALDH1A1NLRP3 | |
| SCHEMBL24392127 | 0.65 | PDE10A (0.41) | PDE3BPDE3APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4134980-A | Phenylalkylamino-alkyl derivatives of quinazolinone and phthalazinone | BOEHRINGER INGELHEIM GMBH (DE) | 1979-01-16 | — | — | US | disclosed |