Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.39 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24077328 | 0.86 | NLRP3 (0.47) | LMNANLRP3GPR139KDM4EKMT2A | |
| SCHEMBL30168576 | 0.86 | NLRP3 (0.47) | LMNANLRP3GPR139KDM4EKMT2A | |
| SCHEMBL24076914 | 0.83 | GAA (0.50) | NLRP3GPR139KDM4EMEN1MAPT | |
| SCHEMBL24076367 | 0.77 | NLRP3 (0.57) | LMNAKAT2BNLRP3GPR139MEN1 | |
| SCHEMBL26630479 | 0.73 | NLRP3 (0.48) | NLRP3GPR139KMT2A | |
| SCHEMBL26738768 | 0.73 | TSHR (0.46) | LMNANLRP3GPR139KDM4EKMT2A | |
| SCHEMBL29426561 | 0.73 | NLRP3 (0.48) | NLRP3GPR139KMT2A | |
| SCHEMBL29426614 | 0.72 | NLRP3 (0.47) | NLRP3GPR139 | |
| SCHEMBL26732715 | 0.72 | NLRP3 (0.47) | NLRP3GPR139 | |
| SCHEMBL24077038 | 0.72 | NLRP3 (0.47) | NLRP3GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021239885-A1 | COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2021-12-02 | — | — | WO | disclosed |