SCHEMBL11548858

SCHEMBL11548858

COc1cccc2cocc12

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.47
ACHE P22303 14/20 0.45
BCHE P06276 10/20 0.45
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA4 P22748 1/20 0.42
CA7 P43166 1/20 0.42
CA9 Q16790 1/20 0.42
CA14 Q9ULX7 1/20 0.42
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.42
HPGD P15428 1/20 0.42
HSD17B10 Q99714 1/20 0.42
CYP2A6 P11509 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28873310 0.78 KDM1A (0.42)
SCHEMBL31094208 0.76 CYP2A6 (0.49) CYP2A6
SCHEMBL31094211 0.74 NR2E1 (0.43) KDM4EALDH1A1HSD17B10
SCHEMBL8393507 0.73 NQO1 (0.67) NQO1ACHEBCHECA12CA1
SCHEMBL29919905 0.73 NQO1 (0.67) NQO1ACHEBCHECA12CA1
SCHEMBL29367279 0.73 MAPT (0.61) NQO1ACHEBCHECA12CA1
SCHEMBL30373629 0.73 MAPT (0.61) NQO1ACHEBCHECA12CA1
SCHEMBL151449 0.73 MAPT (0.61) NQO1ACHEBCHECA12CA1
SCHEMBL357145 0.71 CA1 (0.61) NQO1CA12CA1CA2CA4
SCHEMBL31116611 0.71 CA1 (0.61) NQO1CA12CA1CA2CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4154745-A Isobenzofuran route to anthracycloquinones RESEARCH CORPORATION (US) 1979-05-15 US disclosed
US-4116981-A 5,12-EPOXY-NAPHTHACENE-6,11-DIONE DERIVATIVES Tsay, Yuh-Geng (TW) 1978-09-26 US disclosed