SCHEMBL11548937

SCHEMBL11548937

CC(C#Cc1ccc(-c2cccc(F)c2)cc1)C(C)(C)O

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 1/20 0.45
TAAR1 Q96RJ0 3/20 0.41
FFAR1 O14842 2/20 0.41
PTPN1 P18031 1/20 0.40
MMP1 P03956 2/20 0.38
MMP2 P08253 2/20 0.38
MMP3 P08254 2/20 0.38
MMP7 P09237 2/20 0.38
MMP9 P14780 2/20 0.38
MMP13 P45452 2/20 0.38
MMP8 P22894 1/20 0.38
MMP14 P50281 1/20 0.38
CTSL P07711 1/20 0.36
CTSB P07858 1/20 0.36
CTSS P25774 1/20 0.36
CTSK P43235 1/20 0.36
LGMN Q99538 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11551466 0.85 CYP17A1 (0.36) FFAR1
SCHEMBL11549280 0.83 PGR (0.46) ESR2TAAR1FFAR1MMP1MMP2
SCHEMBL11554410 0.83 ESR2 (0.47) ESR2TAAR1FFAR1PTPN1MMP1
SCHEMBL11555622 0.80 ALOX5 (0.46) FFAR1MMP2MMP3MMP9MMP14
SCHEMBL11548872 0.80 ESR2 (0.50) ESR2TAAR1FFAR1PTPN1
SCHEMBL11552611 0.76 ACACB (0.36) MMP1MMP2MMP3MMP7MMP9
SCHEMBL11551871 0.76 NPSR1 (0.43) PTPN1CTSLCTSBCTSSCTSK
SCHEMBL11550786 0.75 ESR2 (0.45) ESR2TAAR1FFAR1PTPN1CTSL
SCHEMBL11548524 0.72 ALOX5 (0.43) MMP1MMP2MMP9MMP13
SCHEMBL11554876 0.70 CYP2A6 (0.41) FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4151294-A Alkynols and process for their preparation MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1979-04-24 US disclosed