Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL689576 | 0.81 | BRD4 (0.55) | SMN1; SMN2LMNAMEN1KMT2AKDM4E | |
| SCHEMBL30782682 | 0.81 | BRD4 (0.55) | SMN1; SMN2LMNAMEN1KMT2AKDM4E | |
| SCHEMBL8203415 | 0.77 | ALDH1A1 (0.66) | SMN1; SMN2LMNAMEN1KMT2AKDM4E | |
| SCHEMBL11547661 | 0.77 | RAB9A (0.46) | SMN1; SMN2LMNAMEN1KMT2AKDM4E | |
| SCHEMBL4932342 | 0.73 | HCAR2 (0.50) | KDM4EALDH1A1GAAHPGDCYP1A2 | |
| SCHEMBL689847 | 0.73 | PARP1 (0.56) | LMNAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL11546546 | 0.73 | CDK1 (0.45) | KDM4EALDH1A1GAAHPGDRAB9A | |
| SCHEMBL8191558 | 0.72 | ALDH1A1 (0.62) | SMN1; SMN2LMNAMEN1KMT2AKDM4E | |
| SCHEMBL5505353 | 0.72 | SMN1; SMN2 (0.97) | SMN1; SMN2LMNAMEN1KMT2AKDM4E | |
| SCHEMBL31442528 | 0.72 | SMN1; SMN2 (0.97) | SMN1; SMN2LMNAMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4134981-A | ANTIALLERGENS | PFIZER INC. (US) | 1979-01-16 | — | — | US | disclosed |
| US-4120962-A | Fused pyrimidin-4(3H)-ones as antiallergy agents | PFIZER INC. (US) | 1978-10-17 | — | — | US | disclosed |
| US-4044134-A | FUSED WITH QUINOLINE OR PYRIDINE, 2-METHYL, ETHYL, OR ACETYL GROUP | PFIZER INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-3974161-A | Fused pyrimidin-4(3H)-ones as antiallergy agents | PFIZER INC. (US) | 1976-08-10 | — | — | US | disclosed |