Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11549464 | 0.85 | HTT (0.50) | MAPTNPC1RAB9APKMHTT | |
| SCHEMBL11555183 | 0.83 | MAPT (0.42) | MAPTNPC1RAB9AHTTALDH1A1 | |
| SCHEMBL11553028 | 0.83 | MAPT (0.42) | MAPTGRIA4GRIA2PDK2USP7 | |
| SCHEMBL11549319 | 0.80 | MAPT (0.41) | MAPTHTTKDM4E | |
| SCHEMBL11048323 | 0.78 | MAPT (0.64) | MAPTNPC1RAB9APKMHTT | |
| SCHEMBL11548494 | 0.77 | PARP10 (0.43) | MAPTHTTL3MBTL1NPSR1 | |
| SCHEMBL11550786 | 0.76 | ESR2 (0.45) | MAPTGRIA4GRIA2CTSLCTSB | |
| SCHEMBL11551871 | 0.74 | NPSR1 (0.43) | MAPTNPC1RAB9APKMALDH1A1 | |
| SCHEMBL11551589 | 0.74 | MAPT (0.41) | MAPTALDH1A1 | |
| SCHEMBL11550517 | 0.74 | MAPT (0.41) | MAPTL3MBTL1NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4151294-A | Alkynols and process for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-04-24 | — | — | US | disclosed |