Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11546703 | 0.80 | TNKS2 (0.46) | KDM4EGAAALDH1A1MAPTMEN1 | |
| SCHEMBL8198142 | 0.79 | MEN1 (0.56) | PDE3BPDE3AKDM4EGAAPOLB | |
| SCHEMBL11551636 | 0.76 | SRC (0.56) | PDE3BPDE3AKDM4EGAAPOLB | |
| SCHEMBL8643555 | 0.73 | GABRA1 (0.43) | PDE3BPDE3AKDM4EGABRA1GABRA5 | |
| SCHEMBL11546756 | 0.71 | SRC (0.47) | PDE3BPDE3AKDM4EGAAPOLB | |
| SCHEMBL13343441 | 0.69 | KDM4E (0.53) | PDE3BPDE3AKDM4EGAAGABRA1 | |
| SCHEMBL7698174 | 0.67 | PDE3B (0.47) | PDE3BPDE3AKDM4EPOLBTSHR | |
| Pirolate SCHEMBL11546568 | 0.67 | SRC (0.51) | PDE3BPDE3AKDM4EGAAGABRA1 | |
| SCHEMBL27167377 | 0.67 | KDM4E (0.72) | PDE3BPDE3AKDM4EGAAALDH1A1 | |
| SCHEMBL11549583 | 0.66 | SRC (0.56) | PDE3BPDE3AKDM4EGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4134981-A | ANTIALLERGENS | PFIZER INC. (US) | 1979-01-16 | — | — | US | disclosed |
| US-4120962-A | Fused pyrimidin-4(3H)-ones as antiallergy agents | PFIZER INC. (US) | 1978-10-17 | — | — | US | disclosed |
| US-3974161-A | Fused pyrimidin-4(3H)-ones as antiallergy agents | PFIZER INC. (US) | 1976-08-10 | — | — | US | disclosed |