Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11578372 | 0.89 | SMN1; SMN2 (0.37) | MAPTTSHRTDP1POLBKDM4E | |
| SCHEMBL6214637 | 0.89 | MAPT (0.43) | MAPTTSHRTDP1ABL1POLB | |
| SCHEMBL11556626 | 0.87 | SMN1; SMN2 (0.48) | MAPTTSHRTDP1POLBKDM4E | |
| SCHEMBL11580323 | 0.83 | CYP2C19 (0.38) | MAPTTSHRALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7958636 | 0.82 | ERN1 (0.43) | LMNAMEN1KMT2A | |
| SCHEMBL7447957 | 0.81 | MAPT (0.45) | MAPTTSHRTDP1ABL1POLB | |
| SCHEMBL11560889 | 0.81 | GRM5 (0.57) | MAPTALDH1A1GAAL3MBTL1SMN1; SMN2 | |
| SCHEMBL3997777 | 0.79 | GRM5 (0.49) | SMN1; SMN2 | |
| SCHEMBL21077854 | 0.79 | MAPT (0.43) | MAPTTSHRTDP1ABL1POLB | |
| SCHEMBL8117386 | 0.79 | MAPT (0.43) | MAPTTSHRTDP1ABL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000167-A1 | 1,2,3,6-Tetrahydroisonicotinic acid and derivatives thereof, methods and starting products for their preparation, and pharmaceutical compositions containing them. | Krogsgaard-Larsen, Povl (DK) | 1979-01-10 | — | — | EP | disclosed |