Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11554285 | 0.83 | MAPT (0.42) | KMT2AMEN1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL3997777 | 0.82 | GRM5 (0.49) | USP2SMN1; SMN2 | |
| SCHEMBL11557561 | 0.81 | NPY2R (0.46) | CYP2C19KMT2AMEN1MAPK1L3MBTL1 | |
| SCHEMBL11560724 | 0.80 | QDPR (0.46) | KMT2ATSHRGABRPGABRDGABRA1 | |
| SCHEMBL11578372 | 0.80 | SMN1; SMN2 (0.37) | ALDH1A1MAPTTSHRSMN1; SMN2NPC1 | |
| SCHEMBL28275844 | 0.80 | TSHR (0.39) | KMT2AMEN1L3MBTL1ALDH1A1TSHR | |
| SCHEMBL6079220 | 0.79 | L3MBTL1 (0.39) | CYP2C19CYP3A4KMT2AMEN1MAPK1 | |
| SCHEMBL11552932 | 0.78 | GRM5 (0.54) | CYP2C19CYP3A4KMT2AMEN1MAPK1 | |
| SCHEMBL11559895 | 0.77 | CYP1A2 (0.54) | CYP2C19KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL11556626 | 0.77 | SMN1; SMN2 (0.48) | KMT2AMEN1L3MBTL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4511375-A1 | BICYCLIC COMPOUNDS | Aligos Therapeutics, Inc. (US) | 2025-02-26 | — | — | EP | disclosed |
| WO-2023205653-A1 | BICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. (US) | 2023-10-26 | — | — | WO | disclosed |
| EP-0000167-A1 | 1,2,3,6-Tetrahydroisonicotinic acid and derivatives thereof, methods and starting products for their preparation, and pharmaceutical compositions containing them. | Krogsgaard-Larsen, Povl (DK) | 1979-01-10 | — | — | EP | disclosed |