Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.66 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | THRB | P10828 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | DRD4 | P21917 | 1/20 | 0.66 |
| ▸ | HTR1B | P28222 | 1/20 | 0.66 |
| ▸ | HTR2C | P28335 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6451228 | 0.88 | HTR1A (0.72) | HTR1AADRB2ADRB1CYP1A2CYP3A4 | |
| SCHEMBL11449725 | 0.88 | HTR1A (0.63) | HTR1AADRB2ADRB1CYP1A2CYP3A4 | |
| SCHEMBL11457090 | 0.84 | HTR1A (0.64) | HTR1AADRB2ADRB1CYP1A2CYP3A4 | |
| SCHEMBL11450703 | 0.84 | HTR1A (0.47) | HTR1AADRB2ADRB1CYP1A2CYP3A4 | |
| SCHEMBL11450795 | 0.84 | HTR1A (0.66) | HTR1AADRB2ADRB1CYP1A2CYP3A4 | |
| SCHEMBL11457547 | 0.84 | HTR1A (0.63) | HTR1AADRB2ADRB1CYP1A2CYP3A4 | |
| SCHEMBL11449768 | 0.83 | HTR1A (0.45) | HTR1AADRB2ADRB1CYP1A2CYP3A4 | |
| SCHEMBL11459692 | 0.82 | HTR1A (0.67) | HTR1AADRB2ADRB1CYP1A2CYP3A4 | |
| SCHEMBL11450670 | 0.82 | HTR1A (0.61) | HTR1AADRB2ADRB1CYP1A2CYP3A4 | |
| SCHEMBL11459344 | 0.82 | HTR1A (0.63) | HTR1AADRB2ADRB1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4152446-A | Aminopropanol compounds and compositions for the treatment of cardiac and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1979-05-01 | — | — | US | disclosed |