Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.72 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.72 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.72 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.72 |
| ▸ | USP2 | O75604 | 1/20 | 0.72 |
| ▸ | THRB | P10828 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | GLA | P06280 | 1/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11450795 | 0.88 | HTR1A (0.66) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| SCHEMBL11554377 | 0.88 | HTR1A (0.66) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| SCHEMBL9647989 | 0.88 | ADRB2 (0.56) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| SCHEMBL9646944 | 0.88 | ADRB2 (0.56) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| SCHEMBL7328052 | 0.88 | ADRB2 (0.59) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| SCHEMBL9450191 | 0.87 | ADRB2 (0.58) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| SCHEMBL7327939 | 0.87 | ADRB2 (0.55) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| SCHEMBL7336688 | 0.87 | ADRB2 (0.55) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| SCHEMBL10562386 | 0.86 | ADRB2 (0.54) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| SCHEMBL7333097 | 0.86 | ADRB2 (0.57) | HTR1AADRB2ADRB1CYP1A2ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050080084-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of central nervous system damage | PHARMACIA CORPORATION | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080084-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of central nervous system damage | TPH2, TPH1, HTR2A | HTR1A 6/4885ADRB2 396/4885ADRB1 829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.