Phorbol Myristate Acetate

Phorbol Myristate Acetate

SCHEMBL115567

CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H](C=C(CO)C[C@]3(O)C(=O)C(C)=C[C@@H]23)[C@H]2C(C)(C)[C@]12OC(C)=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCA P17252 6/20 1.00
PRKCG P05129 5/20 1.00
PRKCB P05771 5/20 1.00
PRKCH P24723 5/20 1.00
PRKCE Q02156 5/20 1.00
PRKCQ Q04759 5/20 1.00
PRKCD Q05655 5/20 1.00
PRKD3 O94806 4/20 1.00
PRKCI P41743 4/20 1.00
PRKCZ Q05513 4/20 1.00
PRKD1 Q15139 4/20 1.00
USP2 O75604 2/20 1.00
TP53 P04637 2/20 1.00
KDM4E B2RXH2 1/20 1.00
ALDH1A1 P00352 1/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
CYP3A4 P08684 1/20 1.00
CYP2C9 P11712 1/20 1.00
TSHR P16473 1/20 1.00
NFKB1 P19838 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3707129 1.00 PRKCA (1.00) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol Myristate Acetate SCHEMBL22722418 1.00 PRKCA (1.00) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol Myristate Acetate SCHEMBL17368149 1.00 PRKCA (1.00) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol Myristate Acetate SCHEMBL18550994 1.00 PRKCA (1.00) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol Myristate Acetate SCHEMBL22736719 1.00 PRKCA (1.00) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol Myristate Acetate SCHEMBL21165759 1.00 PRKCA (1.00) PRKCAPRKCGPRKCBPRKCHPRKCE
SCHEMBL16174732 1.00 PRKCA (1.00) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol Myristate Acetate SCHEMBL15423125 1.00 PRKCA (1.00) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol Myristate Acetate SCHEMBL19271683 1.00 PRKCA (1.00) PRKCAPRKCGPRKCBPRKCHPRKCE
Phorbol Myristate Acetate SCHEMBL6993831 1.00 PRKCA (1.00) PRKCAPRKCGPRKCBPRKCHPRKCE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 11637 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4743782-A1 METHOD FOR DETECTION OF THE POTENTIAL OF A BODY FLUID SAMPLE TO PRODUCE EXTRACELLULAR TRAPS Belgian Volition SRL (BE) 2026-05-20 EP claimed
CN-122012625-A Viral vector production 牛津生物医学(英国)有限公司 2026-05-12 CN claimed
EP-4719467-A2 METHODS OF MANUFACTURING T CELLS Vittoria Biotherapeutics, Inc. (US) 2026-04-08 EP claimed
US-12590293-B2 Method for obtaining a platelet derived secretome and uses thereof UNIVERSIDAD DE OVIEDO (ES) 2026-03-31 US claimed
US-12566181-B2 Methods and compositions for determining the potency of a therapeutic cellular composition IMMUNOFREE, INC. (US) 2026-03-03 US claimed
US-20260049268-A1 IN VITRO CELL CULTURE MUCUS SYSTEMS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2026-02-19 US claimed
EP-3995139-B1 COMPOSITION FOR USE IN TREATING CANCER UNIV GEORGIA STATE RES FOUND (US) 2026-02-18 EP claimed
US-20260041660-A1 Compositions And Methods for Treating Acute Respiratory Distress Syndrome (ARDS) And Inflammatory Disorders Caused by Corona Viruses and Other Respiratory Pathogens or Agents That Mediate Pulmonary Injury, Inflammation or Acute Respiratory Distress, And Related Compositions and Methods for Treating and Preventing Human SARS Coronavirus Infection, COVID-19 Disease and Related Symptoms CHANG RICHARD L (US) 2026-02-12 US claimed
US-12539289-B2 Phorbol ester compositions and methods of use for treating or reducing the duration of cytopenia BIOSUCCESS BIOTECH COMPANY, LIMITED (US) 2026-02-03 US claimed
EP-4662469-A1 METHODS OF PREPARING AND FREEZING BIOLOGICAL SAMPLES FOR ANALYTICAL USE AND ASSOCIATED COMPOSITIONS Allen Institute (US) 2025-12-17 EP claimed
EP-0470604-A2 PACAP38, proteine with adenylate cyclase activity Takeda Chemical Industries, Ltd. (JP) 1992-02-12 EP claimed
US-5039794-A Tumor egress factor and processes for producing the same OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1991-08-13 US claimed
EP-0349127-A1 Antibody-mediated and ligand-mediated targeting of differentiation-inducers to tumor cells The Biomembrane Institute (US) 1990-01-03 EP claimed
US-4760021-A culturing, separating microphase-like cells, activating with mitogen, isolating DIRECTOR-GENERAL OF AGENCY OF INDUSTRIAL SCIENCE & TECHNOLOGY (JP) 1988-07-26 US claimed
EP-0260708-A2 Tumor egress factor and processes for producing the same OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1988-03-23 EP claimed
US-4613458-A INHIBITS DNA SYNEHESIS OF T CELLS, AUTOIMMUNE DISEASES KYOWA HAKKO KOGYO CO., LTD. (JP) 1986-09-23 US claimed
US-4596774-A Maintaining lymphocytes in medium supplemented with mouse serum while exposing lymphocytes to nitrogen CENTOCOR, INC. (US) 1986-06-24 US claimed
US-4564593-A Messenger RNA, production and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1986-01-14 US claimed
EP-0135592-A1 DNA SYNTHESIS-REPRESSING SUBSTANCE KYOWA HAKKO KOGYO CO., LTD. (JP) 1985-04-03 EP claimed
US-4460685-A Method of enhancing the production of human γ Interferon NEW YORK UNIVERSITY (US) 1984-07-17 US claimed