Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.81 |
| ▸ | KDR | P35968 | 9/20 | 0.81 |
| ▸ | EGFR | P00533 | 7/20 | 0.77 |
| ▸ | BRAF | P15056 | 2/20 | 0.71 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.70 |
| ▸ | LCK | P06239 | 2/20 | 0.70 |
| ▸ | RET | P07949 | 2/20 | 0.70 |
| ▸ | MET | P08581 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | LTK | P29376 | 2/20 | 0.70 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.70 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.70 |
| ▸ | CIT | O14578 | 1/20 | 0.70 |
| ▸ | GAK | O14976 | 1/20 | 0.70 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.70 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.70 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.70 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13529060 | 0.89 | SRC (0.84) | SRCKDREGFRBRAFEPHB4 | |
| SCHEMBL6906285 | 0.89 | KDR (0.82) | SRCKDREGFRBRAFEPHB4 | |
| SCHEMBL828788 | 0.87 | EGFR (1.00) | SRCKDREGFRBRAFEPHB4 | |
| SCHEMBL29483201 | 0.87 | EGFR (1.00) | SRCKDREGFRBRAFEPHB4 | |
| Hydrochloric Acid SCHEMBL30133464 | 0.86 | EGFR (0.98) | SRCKDREGFRBRAFEPHB4 | |
| SCHEMBL31167326 | 0.86 | EGFR (0.78) | SRCKDREGFRBRAFLCK | |
| Hydrochloric Acid SCHEMBL20534441 | 0.86 | EGFR (0.98) | SRCKDREGFRBRAFEPHB4 | |
| SCHEMBL28354308 | 0.85 | SRC (0.77) | SRCKDREGFRBRAFEPHB4 | |
| SCHEMBL28350517 | 0.85 | SRC (0.77) | SRCKDREGFRBRAFEPHB4 | |
| SCHEMBL19154598 | 0.85 | SRC (0.80) | SRCKDREGFRBRAFEPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921362-B2 | 6,7-dialkoxy quinazoline derivatives and methods of treating drug resistant and other tumors | NATCO PHARMA LIMITED (IN) | 2014-12-30 | — | — | US | disclosed |
| US-20110034459-A1 | 6,7-DIALKOXY QUINAZOLINE DERIVATIVES AND METHODS OF TREATING DRUG RESISTANT AND OTHER TUMORS | NATCO PHARMA LTD. (IN) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034459-A1 | 6,7-DIALKOXY QUINAZOLINE DERIVATIVES AND METHODS OF TREATING DRUG RESISTANT AND OTHER TUMORS | ERBB2, EGFR, ERBB3 | SRC 92/4885KDR 228/4885EGFR 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.