Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.77 |
| ▸ | KDR | P35968 | 8/20 | 0.77 |
| ▸ | EGFR | P00533 | 6/20 | 0.72 |
| ▸ | BRAF | P15056 | 2/20 | 0.69 |
| ▸ | LCK | P06239 | 2/20 | 0.69 |
| ▸ | RET | P07949 | 2/20 | 0.69 |
| ▸ | MET | P08581 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | LTK | P29376 | 2/20 | 0.69 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.69 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.69 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.69 |
| ▸ | CIT | O14578 | 1/20 | 0.69 |
| ▸ | GAK | O14976 | 1/20 | 0.69 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.69 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.69 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.69 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28354308 | 1.00 | SRC (0.77) | SRCKDREGFRBRAFLCK | |
| SCHEMBL13529060 | 0.90 | SRC (0.84) | SRCKDREGFRBRAFLCK | |
| SCHEMBL6165865 | 0.86 | HDAC1 (0.73) | SRCKDREGFRBRAFLCK | |
| SCHEMBL6163849 | 0.86 | HDAC1 (0.73) | SRCKDREGFRBRAFLCK | |
| SCHEMBL6906285 | 0.86 | KDR (0.82) | SRCKDREGFRBRAFLCK | |
| SCHEMBL3531151 | 0.86 | SRC (0.86) | SRCKDREGFRBRAFLCK | |
| SCHEMBL28350751 | 0.86 | SRC (0.77) | SRCKDREGFRAURKA | |
| SCHEMBL1155807 | 0.85 | SRC (0.81) | SRCKDREGFRBRAFLCK | |
| SCHEMBL28350757 | 0.85 | SRC (0.73) | SRCKDREGFRBRAFLCK | |
| SCHEMBL28354714 | 0.85 | SRC (0.73) | SRCKDREGFRBRAFLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110746398-A | 4-heterocyclic substituted quinazoline derivative and preparation method and application thereof | 刘沛友 | 2020-02-04 | — | — | CN | disclosed |