Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11557841 | 0.96 | NR1I2 (0.37) | EGFRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11556536 | 0.93 | NR1I2 (0.39) | EGFRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11557099 | 0.91 | GRIN2D (0.42) | EGFRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11561110 | 0.88 | ESR1 (0.40) | EGFRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11562610 | 0.87 | HTR3E (0.36) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL11564840 | 0.87 | NR1I2 (0.39) | EGFRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11557240 | 0.87 | NR1I2 (0.39) | EGFRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11560912 | 0.86 | GRIN2D (0.39) | EGFRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11561213 | 0.86 | TP53 (0.39) | NR1I2MEN1KMT2ATDP1LMNA | |
| SCHEMBL11557592 | 0.84 | ESR1 (0.40) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4147804-A | ANTIARRHYTHMIA AGENTS | WILLIAM H. RORER, INC. (US) | 1979-04-03 | — | — | US | disclosed |