SCHEMBL11564357

SCHEMBL11564357

O=C(O)COc1nc(F)c(Cl)cc1Cl

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ PKM P14618 2/20 0.43
▸ KDM4E B2RXH2 2/20 0.43
▸ HTT P42858 1/20 0.43
▸ TDP1 Q9NUW8 2/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ HIF1A Q16665 1/20 0.41
▸ MCL1 Q07820 1/20 0.41
▸ TSHR P16473 1/20 0.39
▸ PTGDR2 Q9Y5Y4 1/20 0.38
▸ CYP2C19 P33261 1/20 0.38
▸ PTPN7 P35236 1/20 0.37
▸ IAPP P10997 1/20 0.36
▸ MAP3K8 P41279 1/20 0.36
▸ PLAU P00749 2/20 0.36
▸ MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methylamine SCHEMBL11563848 0.95 KDM4E (0.43) PKMKDM4EHTTTDP1KMT2A
Isopropylamine SCHEMBL11567757 0.91 KDM4E (0.40) PKMKDM4EHTTTDP1KMT2A
Monoethanolamine SCHEMBL11566861 0.91 PLAU (0.40) PKMKDM4EHTTTDP1KMT2A
SCHEMBL11562990 0.87 BTK (0.37) PKMKDM4EHTTTDP1KMT2A
SCHEMBL11565377 0.87 LMNA (0.33) PKMKDM4EHTTTDP1KMT2A
Butylamine SCHEMBL11567316 0.87 HTT (0.38) PKMKDM4EHTTTDP1KMT2A
Diisopropanolamine SCHEMBL11566904 0.85 KDM4E (0.37) PKMKDM4EHTTTDP1KMT2A
SCHEMBL11563506 0.85 ALDH1A1 (0.38) KDM4ETDP1KMT2AMAPT
SCHEMBL11566156 0.84 KDM4E (0.36) PKMKDM4EHTTTDP1KMT2A
Triclopyr SCHEMBL37162 0.83 TDP1 (0.45) PKMKDM4EHTTTDP1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11371055-B2 Herbicide resistance genes CORTEVA AGRISCIENCE LLC (US) 2022-06-28 — — US disclosed
EP-3241430-B1 NOVEL HERBICIDE RESISTANCE GENES DOW AGROSCIENCES LLC (US) 2020-08-26 — — EP disclosed
US-10167483-B2 Herbicide resistance genes DOW AGROSCIENCES LLC (US) 2019-01-01 — — US disclosed
EP-3241430-A1 NOVEL HERBICIDE RESISTANCE GENES Dow AgroSciences LLC (US) 2017-11-08 — — EP disclosed
US-20170211087-A1 NOVEL HERBICIDE RESISTANCE GENES PIONEER HI-BRED INTERNATIONAL, INC. 2017-07-27 — — US disclosed
US-20170211087-A1 NOVEL HERBICIDE RESISTANCE GENES PIONEER HI-BRED INTERNATIONAL, INC. 2017-07-27 — — US disclosed
EP-2484202-B1 NOVEL HERBICIDE RESISTANCE GENES DOW AGROSCIENCES LLC (US) 2017-06-07 — — EP disclosed
US-9624505-B2 Uses and detection of herbicide resistance genes for resistance to aryloxyalkanoate herbicides DOW AGROSCIENCES LLC (US) 2017-04-18 — — US disclosed
US-9624505-B2 Uses and detection of herbicide resistance genes for resistance to aryloxyalkanoate herbicides DOW AGROSCIENCES LLC (US) 2017-04-18 — — US disclosed
EP-2145007-B1 NOVEL HERBICIDE RESISTANCE GENES DOW AGROSCIENCES LLC (US) 2017-01-25 — — EP disclosed
EP-2484767-A1 Novel Herbicide resistance genes Dow AgroSciences LLC (US) 2012-08-08 — — EP disclosed
EP-2484202-A1 Novel herbicide resistance genes Dow AgroSciences LLC (US) 2012-08-08 — — EP disclosed
US-20110203017-A1 Novel Herbicide Resistance Genes DOW AGROSCIENCES, LLC (US) 2011-08-18 — — US disclosed
US-20110203017-A1 Novel Herbicide Resistance Genes DOW AGROSCIENCES, LLC (US) 2011-08-18 — — US disclosed
US-20100251432-A1 Novel Herbicide Resistance Genes DOW AGROSCIENCES LLC (US) 2010-09-30 — — US disclosed
US-20100251432-A1 Novel Herbicide Resistance Genes DOW AGROSCIENCES LLC (US) 2010-09-30 — — US disclosed
WO-2008141154-A2 NOVEL HERBICIDE RESISTANCE GENES DOW AGROSCIENCES LLC (US) 2008-11-20 — — WO disclosed
WO-2007053482-A2 NOVEL HERBICIDE RESISTANCE GENES DOW AGROSCIENCES LLC (US) 2007-05-10 — — WO disclosed
US-4180395-A HERBICIDES THE DOW CHEMICAL COMPANY (US) 1979-12-25 — — US disclosed
US-4127582-A FROM A HALOPYRIDINE AND ALKYL HYDROXYALKANOATE THE DOW CHEMICAL COMPANY (US) 1978-11-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110203017-A1 Novel Herbicide Resistance Genes AADAC, AGXT, DDT PKM 1833/4885KDM4E 579/4885HTT 2772/4885
US-20100251432-A1 Novel Herbicide Resistance Genes AADAC, AGXT, DDT PKM 1866/4885KDM4E 437/4885HTT 2763/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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