Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glyphosate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glyphosate SCHEMBL30579950 | 0.87 | LMNA (0.43) | MEN1LMNAHPGDTSHRBLM | |
| Glyphosate SCHEMBL214438 | 0.87 | LMNA (0.43) | MEN1LMNAHPGDTSHRBLM | |
| Glyphosate SCHEMBL30579951 | 0.87 | LMNA (0.43) | MEN1LMNAHPGDTSHRBLM | |
| Glyphosate SCHEMBL1964442 | 0.87 | LMNA (0.43) | MEN1LMNAHPGDTSHRBLM | |
| Glyphosate SCHEMBL16440 | 0.87 | LMNA (0.43) | MEN1LMNAHPGDTSHRBLM | |
| Glyphosate SCHEMBL8515704 | 0.87 | LMNA (0.43) | MEN1LMNAHPGDTSHRBLM | |
| Glyphosate SCHEMBL29694166 | 0.87 | LMNA (0.43) | MEN1LMNAHPGDTSHRBLM | |
| Glyphosate SCHEMBL10482432 | 0.85 | LMNA (0.42) | MEN1LMNAHPGDTSHRBLM | |
| Glyphosate SCHEMBL63406 | 0.85 | LMNA (0.42) | MEN1LMNAHPGDTSHRBLM | |
| Glyphosate SCHEMBL9640971 | 0.85 | LMNA (0.42) | MEN1LMNAHPGDTSHRBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4159901-A | AMINOMETHYLENEPHOSPHONIC ACID, THIOL | MONSANTO COMPANY (US) | 1979-07-03 | — | — | US | disclosed |