Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 13/20 | 0.82 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.82 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.82 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lofentanil SCHEMBL11565496 | 0.90 | OPRM1 (1.00) | OPRM1OPRK1OPRL1OPRD1 | |
| Lofentanil SCHEMBL1649486 | 0.90 | OPRM1 (1.00) | OPRM1OPRK1OPRL1OPRD1 | |
| Lofentanil SCHEMBL26429 | 0.90 | OPRM1 (1.00) | OPRM1OPRK1OPRL1OPRD1 | |
| Lofentanil SCHEMBL1952939 | 0.90 | OPRM1 (1.00) | OPRM1OPRK1OPRL1OPRD1 | |
| Lofentanil SCHEMBL30637157 | 0.88 | OPRM1 (0.96) | OPRM1OPRK1OPRL1OPRD1 | |
| Lofentanil SCHEMBL29361613 | 0.88 | OPRM1 (0.96) | OPRM1OPRK1OPRL1OPRD1 | |
| Lofentanil SCHEMBL123003 | 0.88 | OPRM1 (0.96) | OPRM1OPRK1OPRL1OPRD1 | |
| Lofentanil SCHEMBL18730637 | 0.81 | OPRM1 (0.81) | OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL11567176 | 0.81 | OPRM1 (0.83) | OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL11567179 | 0.81 | OPRM1 (0.83) | OPRM1OPRK1OPRL1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120310140-A1 | DIRECTED DELIVERY OF AGENTS TO NEURAL ANATOMY | SPINAL MODULATION, INC. (US) | 2012-12-06 | — | — | US | disclosed |
| US-4179569-A | ANALGESIC INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-12-18 | — | — | US | disclosed |
| US-3998834-A | ANALGESICS | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-12-21 | — | — | US | disclosed |